Thursday, June 13, 2013

AREDS II Study Resolves Beta-Carotene Issues

By Teri Farley


Age-Related Eye Disease Study 2 or AREDS II is a study of how nutrients can affect the eyesight. The first study, conducted in 2001, had shown that a high level of antioxidants could reduce the risk of blindness up to 25 percent. However, there were problems with the formulation and the second study effectively addressed these issues.

One very debilitating illnesses is that of blindness. In the United States there are nearly one million people that are blind. 90 percent of the blind are older. Eye disease can come about several ways. There are some people who are born blind. This can be as a result of problems in gestation or childbirth. Others go blind as a result of diabetes or they injure their eyes. Most blindness is caused by getting old.

Most treatments that exist today are only good for a limited range of eye diseases and have limited efficacy. One of the most common currently available treatments is laser surgery; while it has been shown to reduce the risks of blindness, the surgery is very costly and could even result in complications. Although not usually severe, the side effects are quite common; some of these include loss of peripheral vision, reduced night vision, worsening visual acuity, and even hemorrhaging.

AREDS, the initial Age-Related Eye Disease Study was finished and released in 2001. This study was begun to review risk factors and history associated with cataracts and AMD. Another purpose was to analyze whether higher doses of antioxidants might affect AMD or cataracts. They looked at a combination of vitamin C, vitamin E, zinc, and beta-carotene.

The research team found that antioxidants in high doses could lessen the chance of blindness. For high risk individuals, such as those with AMD in one of their eyes or intermediate in both, it brought down the risk nearly 25 percent. One of the ingredients in the initial combination was beta-carotene. Later studies showed that beta-carotene increased the possibility of lung cancer in smokers. They also discovered that it had no effect on the incidence of cataracts.

The next study was finished in May 2013 and had some interesting results. One goal that they had was to discern whether an adequate substitute existed for the beta-carotene. They tried lutein and zeaxanthin and found that they were as effective as the beta-carotene. For people at high risk of advanced AMD this is an important consideration and could help lessen the possibility of developing blindness.

Many older persons are on prescription medications. Also, they use many over-the-counter drugs and dietary supplements. High-dose supplemental nutrients could interfere with some of these medications and keep other vital nutrients from properly absorbing.

Laser surgery has some great effects but it is expensive and it can have serious complications. The initial formula discovered in the AREDS II may be a safer alternative to surgery. This study has confirmed that the formula of antioxidants and zinc reduce AMD risk. Furthermore, the study revealed that lutein and zeaxanthin were effective substitutes for beta-carotene. Before using any new medication please be sure to speak to your doctor.




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