Wednesday, July 24, 2013

Enhancing Drug Delivery Through Liposome

By Irma Farrell


Scientists have been working on improving drug delivery to different parts of the body. Delivery vehicles used in this case have different structures and design. The search for a mechanism to deliver the drugs to a specific area has favored the use liposome. The features that scientists are looking for include specificity with receptors, higher payload, stealth mode operation to enhance its circulatory lifetime, less harmful side effects, efficacy and better uptake.

Incredible results have been obtained from testing liposomes over the years. They have shown a great deal of potential that scientists seek to utilize. Some of the admirable aspects with liposomes include enzyme resistance during metabolism, high solubility as well as specificity. Researchers are narrowing down on this element.

The design and structure of liposomes have made it the ideal choice by increasing its ability to absorb drugs chemicals in the body. This structure is also easy to control and will release the drug depending on conditioning. This paves way for lower dosages reducing the level of toxins introduced to the body through drugs. It is one of the ways used to fight harmful side effects. This has made liposomes the best choice when delivering a gene therapy drug.

Liposomal sizes matter and have an effect on how effective the drug will be. They determine the efficacy of drugs, duration of residency in the body and circulation as well. This property makes target drugs easy to deliver and absorb in the body increasing efficacy. This makes the drug more effective. The right size depends on the project at hand and determines the level of success in achieving effectiveness.

Experts in solution formulation use their experience to develop tailor-made solutions depending on individual demands. It takes experience and expertise to generate the liposomal and lipid solutions that make your work effective. They also will assist in optimizing the existing solution using solvents and surfactants.

Solutions are developed using elaborate procedures that include semi-continuous, batched and scalable. The latest equipment are used to increase accuracy and ensure effectiveness. The processes used make it easy to scale these solutions to meet heavy industrial demands. Sterilization and purifications are also carried out. Tangential flows are used during purification. Other available services include homogenization using high pressure as well as extrusion. This will facilitate sizing and solution preparation.

There is a package for such processes as solvent injection, lipid hydration, aseptic processes as well as lyophilization. Liposomal analysis is carried out to determine particle distribution and sizes. Related procedures include electron microscopy, encapsulation efficiency testing and determination of zeta potential. Drug loading is offered in this package.

A track record of quality delivery and commitment to meets the needs of each client define a reliable company. It also is able to produce a range of products to meet dynamic market demands. Manufacturing the solutions under the same roof they are developed minimizes the chances of variations and errors.

The inability of enzymes to detect liposome has endeared it to drug manufacturers. It has responded well on specificity and meets the expectations by developers. This is a dependable element in reducing body toxicity through specific target. This has been achieved through expert design and structuring.




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